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متالوژی::
اصلاح آلی
The number of possible organic modifications is almost infinite, which confers a great versatility to these carrier materials (Manzano and Vallet-Regí 2010).
Before any organic modification, the interaction of the pharmaceutical agent with the silica walls relied on the relationship between the carboxylic acid group from the drug, COOH, and the silanol groups from the
Organic modification has been revealed as the most important factor affecting the drug loading on ordered mesoporous materials.
However, an organic modification of the silica walls of SBA-15 with quaternary alkyl amines (Figure 2.13) changes the hydrophobicity of the carrier surface, which promotes the tryptophan adsorption into the mesopores.
Before any organic modification of the mesoporous glass, the amount of drug loaded is very low, ca. 13 mg/g.
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